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We synthesize advances (20152025) across principal generatorsmitochondrial electron transport, NADPH oxidases, xanthine oxidoreductase and ER/peroxisomal oxidoreductasesto show how compartmental H 2 O 2 microgradients encode reversible cysteine signaling, while iron-rich niches pivot chemistry toward peroxynitrite, Fenton-derived OH, lipid peroxidation and regulated cell death (apoptosis, ferroptosis, parthanatos)